Article

AI-Guided CRISPR Screen Accelerates Discovery of New Drug Targets

2026-02-28

Abstract excerpt

Psoriasis affects over 125 million people worldwide, yet the mechanistic understanding of keratinocyte-driven inflammation remains incomplete, limiting therapeutic innovation beyond costly systemic biologics that are prone to side effects. Here, we performed the first genome-wide CRISPR knockout screen in primary human adult epidermal keratinocytes to systematically identify regulators of IL-17 receptor A (IL17RA)...

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Literature Corpus work: 8d932473-2ae3-519e-82cc-226b39aab34c
DOI: 10.64898/2026.02.26.708368

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