Article
CRISPR/cas9 mediated knockout of an intergenic variant rs6927172 identified IL-20RA as a new risk gene for multiple autoimmune diseases.
Genes and immunity - 1 Feb 2019
Wu Jianfeng, Yang Sirui, Yu Di, Gao Wenjing, Liu Xianjun, Zhang Kun, Fu Xueqi, Bao Wanguo, Zhang Kaiyu, Yu Jiaao, Sun Liankun, Wang Shaofeng
Abstract excerpt
Genetic variants near the tumor necrosis factor-α-induced protein 3 gene (TNFAIP3) at the chromosomal region 6q23 demonstrated significant associations with multiple autoimmune diseases. The signals of associations have been explained to the TNFAIP3 gene, the most likely causal gene. In this study, we employed CRISPR/cas9 genome-editing tool to generate cell lines with deletions including a candidate causal...
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