Article

Tr1 cell-mediated protection against autoimmune disease by intranasal administration of a fusion protein targeting cDC1 cells

2023-04-12

Abstract excerpt

<h4>ABSTRACT</h4> Curative therapies against autoimmune diseases are lacking. Indeed, most of currently available treatments are only targeting symptoms. We have developed a novel strategy for a therapeutic vaccine against autoimmune diseases based on intranasal administration of a fusion protein tolerogen, which consists of a mutant, enzymatically inactive, cholera toxin A1-subunit genetically fused to disease r...

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Literature Corpus work: 8db28b8f-d6f8-5c93-8d1d-80b3e3d10172
DOI: 10.1101/2023.04.11.536382

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