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Heat-inactivated modified vaccinia virus Ankara boosts Th1-biased cellular and humoral immune responses as a vaccine adjuvant by activating the STING-mediated cytosolic DNA-sensing pathway

2021-07-26

Abstract excerpt

<h4>Background</h4> Protein or peptide-based subunit vaccines are promising platforms for combating human cancers and infectious diseases. However, one primary concern regarding subunit vaccines is the relatively weak immune responses induced by proteins or peptides. Therefore, developing novel and effective vaccine adjuvants is critical for the success of subunit vaccines. Modified vaccinia virus (MVA) is a safe...

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Literature Corpus work
3540c46d-5b40-53cd-bf0c-385d264d9531
DOI
10.1101/2021.07.24.453449
Open publication

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