Article

Partial <i>in vivo</i> reprogramming enables injury-free intestinal regeneration via autonomous Ptgs1 induction

2023-02-25

Abstract excerpt

Tissue regeneration after injury involves the dedifferentiation of somatic cells, a natural adaptive reprogramming process that leads to the emergence of injury-responsive cells with fetal-like characteristics in the intestinal epithelium. However, there is no direct evidence that adaptive reprogramming involves a shared molecular mechanism with direct cellular reprogramming. Here, we induced dedifferentiation of...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8b1be147-a457-5c70-8093-c5d8f04048a2
DOI: 10.1101/2023.02.25.530001

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Partial <i>in vivo</i> reprogramming enables injury-free intestinal regeneration via autonomous Ptgs1 inductionDOI 10.1101/2023.02.25.530001Read

Partial in vivo reprogramming enables injury-free intestinal regeneration via autonomous Ptgs1 inductionSemantic proximity Read

Reprogramming cellular identity during intestinal regenerationSemantic proximity Read

TGFB1 Induces Fetal Reprogramming and Enhances Intestinal RegenerationSemantic proximity Read

Establishment of intestinal organoid cultures modeling injury-associated epithelial regenerationSemantic proximity Read

Dedifferentiation, transdifferentiation and cell fusion: in vivo reprogramming strategies for regenerative medicineSemantic proximity Read

A Spatial and Temporal Transcriptomic Atlas of Mouse Intestinal RegenerationSemantic proximity Read

Regenerative Intestinal Stem Cells Induced by Acute and Chronic Injury: The Saving Grace of the Epithelium?Semantic proximity Read

Epigenetic Reprogramming Alters Intestinal Stem Cell Fate in PouchitisSemantic proximity Read

Maturation of human intestinal epithelium from pluripotency <i>in vitro</i>Semantic proximity Read

In vivo reprogramming leads to premature death due to hepatic and intestinal failureSemantic proximity Read

Long-Term Culture Captures Injury-Repair Cycles of Colonic Stem CellsSemantic proximity Read

p53 promotes revival stem cells in the regenerating intestine after severe radiation injurySemantic proximity Read