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Article

LINE-1 Hypomethylation Is Associated With Malignant Traits and Cell Proliferation in Lung Adenocarcinoma.

Anticancer research - 1 Oct 2020

Kitahara Hirokazu, Okamoto Tatsuro, Shimamatsu Shinichiro, Kohno Mikihiro, Morodomi Yosuke, Tagawa Tetsuzo, Kitao Hiroyuki, Okano Shinji, Oda Yoshinao, Maehara Yoshihiko, Mori Masaki

Abstract excerpt

BACKGROUND/AIM: Long interspersed nuclear element-1 (LINE-1) methylation status is a marker for global DNA methylation. However, the relationship between LINE-1 methylation and the biology of lung adenocarcinoma remains unclear. Here, we aimed to examine the role of LINE-1 in lung cancer. MATERIALS AND METHODS: LINE-1 methylation levels were quantified by bisulfite pyrosequencing of resected tumor specimens from...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32988890
DOI: 10.21873/anticanres.14579

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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