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Article

Rare somatic cells from human breast tissue exhibit extensive lineage plasticity

4 Mar 2013

Abstract excerpt

We identified cell surface markers associated with repression of p16(INK4a)/cyclin-dependent kinase inhibitor 2A(CDKN2A), a critical determinant in the acquisition of a plastic state. These cell surface markers allowed direct isolation of rare cells from healthy human breast tissue that exhibit extensive lineage plasticity. This subpopulation is poised to transcribe plasticity markers, OCT3/4, SOX2, and NANOG, at...

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PMID: 23487770
DOI: 10.1073/pnas.1218682110

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