Article
Suppression of endogenous lipogenesis induces reversion of the malignant phenotype and normalized differentiation in breast cancer.
Oncotarget - 1 Nov 2016
Gonzalez-Guerrico Anatilde M, Espinoza Ingrid, Schroeder Barbara, Park Cheol Hong, Kvp Chandra Mohan, Khurana Ashwani, Corominas-Faja Bruna, Cuyàs Elisabet, Alarcón Tomás, Kleer Celina, Menendez Javier A, Lupu Ruth
Abstract excerpt
The correction of specific signaling defects can reverse the oncogenic phenotype of tumor cells by acting in a dominant manner over the cancer genome. Unfortunately, there have been very few successful attempts at identifying the primary cues that could redirect malignant tissues to a normal phenotype. Here we show that suppression of the lipogenic enzyme fatty acid synthase (FASN) leads to stable reversion of...
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