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Article

An AIB1 Isoform Alters Enhancer Access and Enables Progression of Early-Stage Triple-Negative Breast Cancer.

Cancer research - 15 Aug 2021

Sharif Ghada M, Campbell Moray J, Nasir Apsra, Sengupta Surojeet, Graham Garrett T, Kushner Max H, Kietzman William B, Schmidt Marcel O, Pearson Gray W, Loudig Olivier, Fineberg Susan, Wellstein Anton, Riegel Anna T

Abstract excerpt

AIB1Δ4 is an N-terminally truncated isoform of the oncogene amplified in breast cancer 1 (AIB1) with increased expression in high-grade human ductal carcinoma in situ (DCIS). However, the role of AIB1Δ4 in DCIS malignant progression has not been defined. Here we CRISPR-engineered RNA splice junctions to produce normal and early-stage DCIS breast epithelial cells that expressed only AIB1Δ4. These cells showed...

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Identifiers

PMID: 34135000
DOI: 10.1158/0008-5472.CAN-20-3625
PMCID: PMC8373795

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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