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Article

Epigenetic Dynamics in the Function of T-Lineage Regulatory Factor Bcl11b.

Frontiers in immunology - 1 Jan 2021

Sidwell Tom, Rothenberg Ellen V

Abstract excerpt

The transcription factor Bcl11b is critically required to support the development of diverse cell types, including T lymphocytes, type 2 innate lymphoid cells, neurons, craniofacial mesenchyme and keratinocytes. Although in T cell development its onset of expression is tightly linked to T-lymphoid lineage commitment, the Bcl11b protein in fact regulates substantially different sets of genes in different...

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Share to Cell Lineage
Share to Chromatin Assembly and Disassembly
Share to Epigenesis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Developmental

Share to Repressor Proteins

Share to T-Lymphocytes

Share to Transcription, Genetic

Share to Tumor Suppressor Proteins

Source

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Identifiers

PMID: 33936112
DOI: 10.3389/fimmu.2021.669498
PMCID: PMC8079813

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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