Article

Acute pharmacodynamic responses to sitagliptin: Drug-induced increase in early insulin secretion in oral glucose tolerance test

2023-09-25

Abstract excerpt

<h4>Aim</h4> DPP4 inhibitors are widely prescribed as treatments for type 2 diabetes. Because drug responses vary among individuals, we initiated investigations to identify genetic variants associated with the magnitude of drug responses. <h4>Methods</h4> Sitagliptin (100 mg) was administered to 47 healthy volunteers. Several endpoints were measured to assess clinically relevant responses – including the effect of...

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Literature Corpus work: 8d48bc5d-b447-515d-ab80-5a1c6deddcff
DOI: 10.1101/2023.09.24.23296026

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