One-hour glucose-defined metabolic phenotypes in youth with obesity: early β-cell impairment across the spectrum of dysglycemia.

doi:10.1016/j.diabres.2026.113420

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Article

One-hour glucose-defined metabolic phenotypes in youth with obesity: early β-cell impairment across the spectrum of dysglycemia.

Diabetes research and clinical practice - 1 Sept 2026

Deligozoglu Duygu, Cetin Sirmen Kızılcan, Gokdemir Irem, Cetin Murat, Omurbek Cansu Ece, Işik Emregul, Buyukyilmaz Gonul, Tepe Derya, Kocaay Pınar, Boyraz Mehmet, Gürbüz Fatih

Abstract excerpt

AIMS: To characterize oral glucose tolerance test (OGTT)-derived metabolic phenotypes in children and adolescents with obesity, focusing on the clinical significance of elevated 1-hour plasma glucose. METHODS: This retrospective study included 726 children and adolescents with obesity who underwent an OGTT at a tertiary center. Participants were classified as NGT-Low (1-hour glucose < 155 mg/dL), NGT-High...

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Blood Glucose
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PMID: 42401294
DOI: 10.1016/j.diabres.2026.113420

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