Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evaluation of fasting state-/oral glucose tolerance test-derived measures of insulin release for the detection of genetically impaired β-cell function.

PloS one - 2 Dec 2010

Herzberg-Schäfer Silke A, Staiger Harald, Heni Martin, Ketterer Caroline, Guthoff Martina, Kantartzis Konstantinos, Machicao Fausto, Stefan Norbert, Häring Hans-Ulrich, Fritsche Andreas

Abstract excerpt

BACKGROUND: To date, fasting state- and different oral glucose tolerance test (OGTT)-derived measures are used to estimate insulin release with reasonable effort in large human cohorts required, e.g., for genetic studies. Here, we evaluated twelve common (or recently introduced) fasting state-/OGTT-derived indices for their suitability to detect genetically determined β-cell dysfunction. METHODOLOGY/PRINCIPAL...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Area Under Curve
Share to Blood Glucose

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to C-Peptide

Share to Fasting

Share to Glucose Tolerance Test

Share to Insulin

Share to Insulin-Secreting Cells

Share to Regression Analysis

Source

Open in PubMed Open full text

Identifiers

PMID: 21152029
DOI: 10.1371/journal.pone.0014194
PMCID: PMC2996282

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evaluation of fasting state-/oral glucose tolerance test-derived measures of insulin release for the detection of genetically impaired β-cell function.PMID 21152029Read ↗

Comprehensive validation of fasting- and oral glucose tolerance test-based indices of insulin secretion against gold-standard measuresSemantic proximity Read ↗

Genetic and phenotypic correlations between surrogate measures of insulin release obtained from OGTT data.Semantic proximity Read ↗

Genetic Underpinnings of Fasting and Oral Glucose-stimulated Based Insulin Sensitivity Indices.Semantic proximity Read ↗

Estimating Insulin Sensitivity and Beta-Cell Function from the Oral Glucose Tolerance Test: Validation of a new Insulin Sensitivity and Secretion (ISS) ModelSemantic proximity Read ↗

Combined risk allele score of eight type 2 diabetes genes is associated with reduced first-phase glucose-stimulated insulin secretion during hyperglycemic clamps.Semantic proximity Read ↗

Joint effect of insulin signaling genes on insulin secretion and glucose homeostasis.Semantic proximity Read ↗

Human Physiology of Genetic Defects Causing Beta-cell Dysfunction.Semantic proximity Read ↗

Evaluation of genetic predisposition to insulin resistance by nutrient-induced insulin output ratio (NIOR).Semantic proximity Read ↗

Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans.Semantic proximity Read ↗

Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men.Semantic proximity Read ↗

Heritability of model-derived parameters of beta cell secretion during intravenous and oral glucose tolerance tests: a study of twins.Semantic proximity Read ↗

Profiles of Glucose Metabolism in Different Prediabetes Phenotypes, Classified by Fasting Glycemia, 2-Hour OGTT, Glycated Hemoglobin, and 1-Hour OGTT: An IMI DIRECT Study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.