Article

Pharmacogenetics of SGLT2 Inhibitors: Validation of a sex-agnostic pharmacodynamic biomarker

2023-03-09

Abstract excerpt

<h4>Aim</h4> SGLT2 inhibitors provide multiple benefits to patients with type 2 diabetes – including improved glycemic control and decreased risks of cardiorenal disease. Because drug responses vary among individuals, we initiated investigations to identify genetic variants associated with the magnitude of drug responses. <h4>Methods</h4> Canagliflozin (300 mg) was administered to 30 healthy volunteers. Several en...

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Literature Corpus work: b50419d3-26e1-573f-b573-1c8d9ace77ef
DOI: 10.1101/2023.03.07.23286875

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