Article

Exploitation of CD3ζ to enhance TCR expression levels and antigen-specific T cell function

2024-02-16

Abstract excerpt

The expression levels of TCRs on the surface of human T cells define the avidity of TCR-HLA/peptide interactions. In this study, we have explored which components of the TCR-CD3 complex are involved in determining the surface expression levels of TCRs in primary human T cells. The results show that there is a surplus of endogenous TCR α/β chains that can be mobilised by providing T cells with additional CD3γ,δ,ε,ζ...

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Literature Corpus work: 8d43697c-cf38-5f1f-98f3-7296816abef3
DOI: 10.1101/2024.02.14.580308

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