Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The CD3-gamma and CD3-delta subunits of the T cell antigen receptor can be expressed within distinct functional TCR/CD3 complexes.

The EMBO journal - 1 Apr 1991

Alarcón B, Ley S C, Sánchez-Madrid F, Blumberg R S, Ju S T, Fresno M, Terhorst C

Abstract excerpt

The T cell receptor for antigen (TCR) consists of two glycoproteins containing variable regions (TCR-alpha/beta or TCR-gamma/delta) which are expressed on the cell surface in association with at least four invariant proteins (CD3-gamma, -delta, -epsilon and -zeta). CD3-gamma and CD3-delta chains are highly homologous, especially in the cytoplasmic domain. The similarity observed in their genomic organization and...

Topics

Animals
Antibodies, Monoclonal
Antigens, CD
Antigens, Differentiation, T-Lymphocyte
CD3 Complex
Cell Line
Cell Membrane
Genetic Variation
Humans
Macromolecular Substances
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Multigene Family

Receptors, Antigen, T-Cell

T-Lymphocytes

Thymus Gland

Transfection

Source

Open in PubMed Open full text

Identifiers

PMID: 1826255
DOI: 10.1002/j.1460-2075.1991.tb08023.x
PMCID: PMC452733

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1826255-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The CD3-gamma and CD3-delta subunits of the T cell antigen receptor can be expressed within distinct functional TCR/CD3 complexes.PMID 1826255Read ↗

Structure of the T-cell antigen receptor: evidence for two CD3 epsilon subunits in the T-cell receptor-CD3 complex.Semantic proximity Read ↗

Assembly of the TCR/CD3 complex: CD3ε/δ and CD3ε/γ dimers associate indistinctly with both TCRα and TCRβ chains. Evidence for a double TCR heterodimer modelSemantic proximity Read ↗

Association of the human CD3-zeta chain with the alpha beta-T cell receptor/CD3 complex. Clues from a T cell variant with a mutated T cell receptor-alpha chain.Semantic proximity Read ↗

The CD3gamma chain is essential for development of both the TCRalphabeta and TCRgammadelta lineages.Semantic proximity Read ↗

Conformational and biochemical differences in the TCR.CD3 complex of CD8(+) versus CD4(+) mature lymphocytes revealed in the absence of CD3gamma.Semantic proximity Read ↗

Exploitation of CD3ζ to enhance TCR expression levels and antigen-specific T cell functionSemantic proximity Read ↗

Characterization of the lymphocyte activation gene 3-encoded protein. A new ligand for human leukocyte antigen class II antigens.Semantic proximity Read ↗

Independent mutations of the human CD3-epsilon gene resulting in a T cell receptor/CD3 complex immunodeficiency.Semantic proximity Read ↗

Variability of invariant mouse CD3epsilon chains detected by anti-CD3 antibodies.Semantic proximity Read ↗

Biochemical differences in the alphabeta T cell receptor.CD3 surface complex between CD8+ and CD4+ human mature T lymphocytes.Semantic proximity Read ↗

CD3 delta immunodeficiency.Semantic proximity Read ↗

CD3 delta establishes a functional link between the T cell receptor and CD8.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.