The impact of CD3ζ ITAM multiplicity and sequence on CAR T-cell survival and function

Abstract excerpt

Introduction Chimeric antigen receptor (CAR) expressing T-cells have shown great promise for the future of cancer immunotherapy with the recent clinical successes achieved in treating different hematologic cancers. Despite these early successes, several challenges remain in the field that require to be solved for the therapy to be more efficacious. One such challenge is the lack of long-term persistence of CD28...

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