Article
Expression based polygenic scores - A gene network perspective to capture individual differences in biological processes
2024-03-04
Abstract excerpt
Incorporating functional aspects into polygenic scores may accelerate early diagnosis and the discovery of therapeutic targets. Yet, existing polygenic scores summarize information from genome wide statistical associations between SNPs and phenotypes. We developed the novel biologically informed, expression-based polygenic scores (ePRS or ePGS). The method characterizes tissue specific gene co-expression networks...
Topics
Open a Topic to create a Post that cites this publication.
Identifiers and source
- Literature Corpus work
- 8d340c03-6430-5771-b0ea-26f4ab470221
- DOI
- 10.1101/2024.03.01.583008