Article

Engineered Self-Regulating Macrophages for Targeted Anti-inflammatory Drug Delivery

2024-05-31

Abstract excerpt

<title>Abstract</title> <p>Background Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by increased levels of inflammation that primarily manifests in the joints. Macrophages act as key drivers for the progression of RA, contributing to the perpetuation of chronic inflammation and dysregulation of pro-inflammatory cytokines such as interleukin 1 (IL-1). The goal of this study was to devel...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2b59f421-3201-552d-8d62-b5457dc72974
DOI: 10.21203/rs.3.rs-4385938/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Engineered Self-Regulating Macrophages for Targeted Anti-inflammatory Drug DeliveryDOI 10.21203/rs.3.rs-4385938/v1Read

Macrophage-based therapeutic strategies in regenerative medicine.Semantic proximity Read

A Synthetic Gene Circuit for Self-Regulating Delivery of Biologic Drugs in Engineered TissuesSemantic proximity Read

Immunotherapy with Pro-regenerative Macrophages from Embryonic Stem Cells Ameliorate Osteoarthritis via TNFAIP3-Mediated ChondroprotectionSemantic proximity Read

Microneedles loaded with cerium-manganese oxide nanoparticles for targeting macrophages in the treatment of rheumatoid arthritisSemantic proximity Read

A Dual-Fluorescence Assay for Gene Delivery Vehicle Screening in Macrophages with an Inflammation-Inducible Reporter ConstructSemantic proximity Read

Airway Delivery of Encapsulated Cytokine-Secreting Cells for Local Immunomodulation in Inflammatory Lung DiseasesSemantic proximity Read

Macrophages: Redefining extracellular matrix architecture through phenotypic switches as therapeutic targets.Semantic proximity Read

Programmable synthetic cytokine receptors polarize macrophages to user-defined functional statesSemantic proximity Read

A Genome-engineered Bioartificial Implant for Autoregulated Anti-Cytokine Drug DeliverySemantic proximity Read

Platelet-derived exosomes in situ reprogramming macrophages for rheumatoid arthritis treatmentSemantic proximity Read

Macrophage Gene Therapy: opening novel therapeutic avenues for immune disordersSemantic proximity Read

“Immunomodulatory nanoparticles elicit antifibrotic monocyte activation to resolve murine pulmonary fibrosis”Semantic proximity Read