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Article

Mitochondrial targeted antioxidant Peptide ameliorates hypertensive cardiomyopathy.

Journal of the American College of Cardiology - 28 Jun 2011

Dai Dao-Fu, Chen Tony, Szeto Hazel, Nieves-Cintrón Madeline, Kutyavin Vassily, Santana Luis F, Rabinovitch Peter S

Abstract excerpt

OBJECTIVES: We investigated the effect of reducing mitochondrial oxidative stress by the mitochondrial-targeted antioxidant peptide SS-31 in hypertensive cardiomyopathy. BACKGROUND: Oxidative stress has been implicated in hypertensive cardiovascular diseases. Mitochondria and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase have been proposed as primary sites of reactive oxygen species (ROS)...

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Identifiers

PMID: 21620606
DOI: 10.1016/j.jacc.2010.12.044
PMCID: PMC3742010

Genes

NOX4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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