Article

Clinical failure of anti-tau and anti-synuclein antibodies in neurodegeneration: a quantitative systems pharmacology model analysis

2023-05-02

Abstract excerpt

Misfolded proteins in Alzheimer’s disease (AD) and Parkinson’s disease (PD) follow a well-defined connectomics-based spatial progression. Several anti-tau and anti-alpha synuclein (aSyn) antibodies have failed to provide clinical benefit in clinical trials despite substantial target engagement in the experimentally accessible cerebrospinal fluid (CSF). The proposed mechanism of action is reducing neuronal uptake o...

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Literature Corpus work: 8d197045-49b7-51e2-b271-f73afd3d18c7
DOI: 10.21203/rs.3.rs-2799205/v1

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