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Article

Highly specific and selective anti‐pS396‐tau antibody C10.2 targets seeding‐competent tau

1 Jan 2018

Abstract excerpt

INTRODUCTION: The abnormal hyperphosphorylation of the microtubule-associated protein tau plays a crucial role in neurodegeneration in Alzheimer's disease (AD) and other tauopathies. METHODS: Highly specific and selective anti-pS396-tau antibodies have been generated using peptide immunization with screening against pathologic hyperphosphorylated tau from rTg4510 mouse and AD brains and selection in in vitro and...

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Identifiers

PMID: 30386817
DOI: 10.1016/j.trci.2018.09.005

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