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Article

Effects of ADAMTS14 genetic polymorphism and cigarette smoking on the clinicopathologic development of hepatocellular carcinoma.

PloS one - 1 Jan 2017

Sheu Ming-Jen, Hsieh Ming-Ju, Chou Ying-Erh, Wang Po-Hui, Yeh Chao-Bin, Yang Shun-Fa, Lee Hsiang-Lin, Liu Yu-Fan

Abstract excerpt

BACKGROUND: ADAMTS14 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs), which are proteolytic enzymes with a variety of further ancillary domain in the C-terminal region for substrate specificity and enzyme localization via extracellular matrix association. However, whether ADAMTS14 genetic variants play a role in hepatocellular carcinoma (HCC) susceptibility remains...

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Source

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Identifiers

PMID: 28231306
DOI: 10.1371/journal.pone.0172506
PMCID: PMC5322915

Genes

ADAMTS14

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