Article

Mosaic Loss of Y chromosome associates with lung function, emphysema and epigenetic aging

2025-07-30

Abstract excerpt

Mosaic loss of Y chromosome (mLOY) in blood cells is an age-related somatic mutation, but its relationship with pulmonary health remains undercharacterized. Leveraging mLOY assessment in over 12,000 men, including 5,097 from the COPDGene Study and 7,235 from six additional cohorts in Trans-Omics for Precision Medicine program, we investigated its association with respiratory outcomes and epigenetic aging. Cross-se...

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Literature Corpus work: e02ed1d2-ff78-50f8-848b-2b7eddea8973
DOI: 10.1101/2025.07.30.25332379

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