Article
Enhancing top-down proteomics of brain tissue with FAIMS
2021-01-19
Abstract excerpt
Proteomic investigations of Alzheimer’s and Parkinson’s disease have provided valuable insights into neurodegenerative disorders. Thus far, these investigations have largely been restricted to bottom-up approaches, hindering the degree to which one can characterize a protein’s “intact” state. Top-down proteomics (TDP) overcomes this limitation, however it is typically limited to observing only the most abundant pr...
Topics
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- Advanced Proteomics Techniques and Applications
- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Metabolomics and Mass Spectrometry Studies
- Mitochondrial Function and Pathology
- Neuroinflammation and Neurodegeneration Mechanisms
- Peptidase Inhibition and Analysis
- Ubiquitin and proteasome pathways
Identifiers and source
- Literature Corpus work
- 4a5ef916-c879-5f94-9d67-9502296d8a22
- DOI
- 10.1101/2021.01.18.427216