Article

Assessing the Clinical Outcomes of Voxelotor Treatment in Patients with Sickle Cell Disease

2024-03-31

Abstract excerpt

The results of Voxelotor treatment in Sickle Cell Disease, as assessed through clinical outcomes, demonstrated its efficacy in reducing hemolysis and improving hemoglobin levels. This effect can be attributed to Voxelotor's inhibition of HbS polymerization, thereby restoring the deformability and compliance of sickle RBCs. Our mathematical model provided mechanistic insights into how altered rheological properties...

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Hemoglobinopathies and Related Disorders

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Literature Corpus work: 8cddd9eb-93c8-5b75-a3f9-1c1e051d3a72
DOI: 10.3126/ijasbt.v12i1.64057

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