Article

Targeting PIEZO1-TMEM16F Coupling to Mitigate Sickle Cell Disease Complications

2025-05-31

Abstract excerpt

A deeper understanding of sickle cell disease (SCD) pathophysiology is critical for identifying novel therapeutic targets. A hallmark of SCD is abnormal phosphatidylserine (PS) exposure on sickle red blood cells (RBCs), which contributes to anemia, thrombosis, and vaso-occlusive crises (VOC). However, the mechanisms underlying this excessive PS exposure remain unclear. Here, we identify TMEM16F, a Ca 2+ -activate...

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Literature Corpus work: 2153b851-a98b-51bf-92f5-20869d1d0bec
DOI: 10.1101/2025.05.27.656389

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