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Article

Patient-specific modeling of individual sickle cell behavior under transient hypoxia

13 Mar 2017

Abstract excerpt

Sickle cell disease (SCD) is a highly complex genetic blood disorder in which red blood cells (RBC) exhibit heterogeneous morphology changes and decreased deformability.We employ a kinetic model for cell morphological sickling that invokes parameters derived from patient-specific data.This model is used to investigate the dynamics of individual sickle cells in a capillary-like microenvironment in order to address...

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PMID: 28288152
DOI: 10.1371/journal.pcbi.1005426

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