Article

Rapid withdrawal of Voxelotor can precipitate sickle cell disease related crisis

2025-04-23

Abstract excerpt

<title>Abstract</title> <p>Sickle cell disease (SCD) is an inherited disorder characterized by abnormal mutation leading to formation of sickle red blood cells. The initial step is the formation of polymers and precipitation of Hemoglobin within the cell. Voxelotor is a novel anti-polymerization drug approved for treatment of patients with SCD, resulting in improved hemoglobin level. Recently its clinical develop...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 02d43e5e-4d3c-5919-9840-108671aa7932
DOI: 10.21203/rs.3.rs-5910575/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Rapid withdrawal of Voxelotor can precipitate sickle cell disease related crisisDOI 10.21203/rs.3.rs-5910575/v1Read

Osivelotor for the treatment of sickle cell diseaseSemantic proximity Read

Sickle Cell Disease in Brazil: Current Management.Semantic proximity Read

Voxelotor Treatment Interferes With Quantitative and Qualitative Hemoglobin Variant Analysis in Multiple Sickle Cell Disease Genotypes.Semantic proximity Read

Assessing the Clinical Outcomes of Voxelotor Treatment in Patients with Sickle Cell DiseaseSemantic proximity Read

Hope on the Horizon: New and Future Therapies for Sickle Cell DiseaseSemantic proximity Read

Methemoglobin aggregation is modulated by the anti-sickling drug voxelotorSemantic proximity Read

Voxelotor in adolescents and adults with sickle cell disease (HOPE): long-term follow-up results of an international, randomised, double-blind, placebo-controlled, phase 3 trial.Semantic proximity Read

Emerging drugs in randomized controlled trials for sickle cell disease: are we on the brink of a new era in research and treatment?Semantic proximity Read

In Silico Post-screening of Anti-polymerization Agents to Treat Sickle Cell DiseaseSemantic proximity Read

The use of FDA-approved medications for preventing vaso-occlusive events in sickle cell diseaseSemantic proximity Read

Insight into the complex pathophysiology of sickle cell anaemia and possible treatmentSemantic proximity Read

A Case of Vaso-Occlusive Crisis in a Patient with Sickle Cell Disease: A Case ReportSemantic proximity Read