Article
Standardized microfluidic assessment of red blood cell-mediated microcapillary occlusion: Association with clinical phenotype and hydroxyurea responsiveness in sickle cell disease.
Microcirculation (New York, N.Y. : 1994) - 1 Feb 2021
Man Yuncheng, Kucukal Erdem, An Ran, Bode Allison, Little Jane A, Gurkan Umut A
Abstract excerpt
OBJECTIVES: We present a standardized in vitro microfluidic assay and Occlusion Index (OI) for the assessment of red blood cell (RBC)-mediated microcapillary occlusion and its clinical associations in sickle cell disease (SCD). METHODS: Red blood cell mediated microcapillary occlusion represented by OI and its clinical associations were assessed for seven subjects with hemoglobin-SC disease (HbSC), 18 subjects...
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