Article

Atheroprone Flow Activates SMAD-FOXO1 to drive Endothelial-to-Mesenchymal Transition and Atherosclerosis

2024-11-29

Abstract excerpt

<h4>Background</h4> Cardiovascular diseases are the leading cause of death worldwide with atherosclerosis as the main underlying pathology. A hallmark of atherosclerotic lesion formation is endothelial-to-mesenchymal transition (EndoMT) triggered by perturbed blood flow patterns at arterial bifurcations and curvatures. SMAD transcription factors (TFs), activated by bone morphogenetic protein (BMP) 9/10 or transfo...

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Literature Corpus work: 86a8d40f-7781-51dd-8a88-cdad2941e09a
DOI: 10.1101/2024.11.25.625323

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