Article
Regional determinants of arterial endothelial phenotype dominate the impact of gender or short-term exposure to a high-fat diet.
Biochemical and biophysical research communications - 24 Jun 2005
Passerini Anthony G, Shi Congzhu, Francesco Nadeene M, Chuan Peiying, Manduchi Elisabetta, Grant Gregory R, Stoeckert Christian J, Karanian John W, Wray-Cahen Diane, Pritchard William F, Davies Peter F
Abstract excerpt
Regional arterial hemodynamics correlates with distinct endothelial phenotypes that may be modified by risk factors to influence focal and regional susceptibility to atherosclerosis. We compared endothelial transcript profiles from hemodynamically distinct arterial regions in 15 mature pigs: males and females fed a normal diet, and males fed a high-fat diet (15% lard, 1.5% cholesterol) for two weeks. Hierarchical...
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