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Article

Amplification of the <i>neu/erbB-2</i> oncogene in a mouse model of mammary tumorigenesis

14 Mar 2000

Abstract excerpt

The neu (c-erbB-2, Her-2) protooncogene is amplified and overexpressed in 20-30% of human breast cancers. Although transgenic mouse models have illustrated the role of Neu in the induction of mammary tumors, Neu expression in these models is driven by a strong viral promoter of questionable relevance to the human disease. To ascertain whether expression of activated Neu under the control of the endogenous...

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PMID: 10716706
DOI: 10.1073/pnas.97.7.3444

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Amplification of the <i>neu/erbB-2</i> oncogene in a mouse model of mammary tumorigenesisPMID 10716706Read ↗

Oncogenic activating mutations in the neu/erbB-2 oncogene are involved in the induction of mammary tumors.Semantic proximity Read ↗

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Novel activating mutations in the neu proto-oncogene involved in induction of mammary tumors.Semantic proximity Read ↗

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Distinct ErbB-2 coupled signaling pathways promote mammary tumors with unique pathologic and transcriptional profiles.Semantic proximity Read ↗

ErbB2 Transgenic Mice: A Tool for Investigation of the Immune Prevention and Treatment of Mammary CarcinomasSemantic proximity Read ↗

Insights from transgenic mouse models of ERBB2-induced breast cancer.Semantic proximity Read ↗

Grb2 and Shc adapter proteins play distinct roles in Neu (ErbB-2)-induced mammary tumorigenesis: implications for human breast cancer.Semantic proximity Read ↗

MMTV promoter hypomethylation is linked to spontaneous and MNU associated c-neu expression and mammary carcinogenesis in MMTV c-neu transgenic mice.Semantic proximity Read ↗

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β-Catenin Signaling Is a Critical Event in ErbB2-Mediated Mammary Tumor ProgressionSemantic proximity Read ↗

Susceptibility loci affecting ERBB2/neu-induced mammary tumorigenesis in mice.Semantic proximity Read ↗

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