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Glioma-derived CCL2 and CCL7 mediate migration of immune suppressive CCR2 <sup>+</sup> myeloid cells into the tumor microenvironment in a redundant manner

2022-07-08

Abstract excerpt

Glioblastoma (GBM) is the most common and malignant primary brain tumor, resulting in poor survival despite aggressive therapies. GBM is characterized in part by a highly heterogeneous and immunosuppressive tumor microenvironment (TME) made up predominantly of infiltrating peripheral immune cells. One significant immune cell type that contributes to glioma immune evasion is a population of immunosuppressive, hemat...

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Literature Corpus work
8c979ca3-3f98-5d77-9b3e-83cb636a70c9
DOI
10.1101/2022.07.08.499173
Open publication

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Glioma-derived CCL2 and CCL7 mediate migration of immune suppressive CCR2 <sup>+</sup> myeloid cells into the tumor microenvironment in a redundant mannerDOI 10.1101/2022.07.08.499173
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