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Article

Insights in the immunobiology of glioblastoma.

Journal of molecular medicine (Berlin, Germany) - 1 Jan 2020

Strepkos Dimitrios, Markouli Mariam, Klonou Alexia, Piperi Christina, Papavassiliou Athanasios G

Abstract excerpt

Glioblastoma, a grade IV astrocytoma, is considered as the most malignant intracranial tumor, characterized by poor prognosis and therapy resistance. Tumor heterogeneity that often leads to distinct functional phenotypes contributes to glioblastoma (GB) indispensable growth and aggressiveness. The complex interaction of neoplastic cells with tumor microenvironment (TME) along with the presence of cancer stem-like...

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PMID: 31650201
DOI: 10.1007/s00109-019-01835-4

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