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Chemokine signaling in tumors: potential role of CXC chemokines and their receptors as glioblastoma therapeutic targets

1 Nov 2024

Abstract excerpt

INTRODUCTION: Glioblastoma is the most aggressive brain tumor, typically associated with poor prognosis. Its treatment is challenging due to the peculiar glioblastoma cell biology and its microenvironment complexity. Specifically, a small fraction of glioma stem cells within the tumor mass drives tumor growth and invasiveness by hijacking brain resident and immune cells. This process also involves modification of...

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PMID: 39582130
DOI: 10.1080/14728222.2024.2433130

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