Article

Re-programming of GM-CSF-dependent alveolar macrophages through GSK3 activity modulation

2024-08-20

Abstract excerpt

<h4>SUMMARY</h4> Monocyte-derived macrophages recruited into inflamed tissues can acquire an array of functional states depending on the extracellular environment. Since the anti-inflammatory/pro-fibrotic macrophage profile is determined by MAFB, whose activity/protein levels are regulated by GSK3, we addressed the macrophage re-programming potential of GSK3 modulation. GM-CSF-dependent (GM-MØ) and M-CSF-dependen...

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Literature Corpus work: 8c94520d-3765-5114-863c-0f7dabfd3181
DOI: 10.1101/2024.08.20.608749

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