Rab1b facilitates lipid droplet growth by ER-to-lipid droplet targeting of DGAT2.

doi:10.1126/sciadv.ade7753

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Article

Rab1b facilitates lipid droplet growth by ER-to-lipid droplet targeting of DGAT2.

Science advances - 31 May 2024

Malis Yehonathan, Armoza-Eilat Shir, Nevo-Yassaf Inbar, Dukhovny Anna, Sklan Ella H, Hirschberg Koret

Abstract excerpt

Lipid droplets (LDs) comprise a triglyceride core surrounded by a lipid monolayer enriched with proteins, many of which function in LD homeostasis. How proteins are targeted to the growing LD is still unclear. Rab1b, a GTPase regulating secretory transport, was recently associated with targeting proteins to LDs in a Drosophila RNAi screen. LD formation was prevented in human hepatoma cells overexpressing...

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Share to Diacylglycerol O-Acyltransferase
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PMID: 38809969
DOI: 10.1126/sciadv.ade7753
PMCID: PMC11135398

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