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RAB5 NUCLEOTIDE BINDING PROMOTES β-OXIDATION TO FUEL HEPATOCELLULAR CARCINOMA CELL PROLIFERATION

2025-08-24

Abstract excerpt

Altered lipid metabolism and lipid droplet (LD) dynamics are hallmark features of hepatocellular carcinoma (HCC) subtypes, but the molecular mechanisms governing LD trafficking and catabolism in HCC cells remain unclear. The small GTPase Rab5, a key regulator of early endosomal dynamics, has been observed to localize to the surface of LDs, suggesting it may play a role in LD turnover. However, the regulation of Ra...

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Literature Corpus work
d07245d7-88d3-5463-8e6d-943cf5072398
DOI
10.1101/2025.08.20.670915
Open publication

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RAB5 NUCLEOTIDE BINDING PROMOTES β-OXIDATION TO FUEL HEPATOCELLULAR CARCINOMA CELL PROLIFERATIONDOI 10.1101/2025.08.20.670915
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