Article

The OSUMMER lines: a series of ultraviolet-accelerated NRAS-mutant mouse melanoma cell lines syngeneic to C57BL/6

2022-12-11

Abstract excerpt

<h4>ABSTRACT</h4> An increasing number of cancer subtypes are treated with front-line immunotherapy. However, approaches to overcome primary and acquired resistance remain limited. Pre-clinical mouse models are often used to investigate resistance mechanisms, novel drug combinations, and delivery methods; yet most of these models lack the genetic diversity and mutational patterns observed in human tumors. Here we...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8c89c2fd-4263-5880-96e4-eecb93eba4f3
DOI: 10.1101/2022.12.09.519766

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The OSUMMER lines: a series of ultraviolet-accelerated NRAS-mutant mouse melanoma cell lines syngeneic to C57BL/6DOI 10.1101/2022.12.09.519766Read

The OSUMMER lines: A series of ultraviolet-accelerated NRAS-mutant mouse melanoma cell lines syngeneic to C57BL/6.Semantic proximity Read

C57BL/6 congenic mouse NRASQ61K melanoma cell lines are highly sensitive to the combination of Mek and Akt inhibitors in vitro and in vivoSemantic proximity Read

The YUMM lines: a series of congenic mouse melanoma cell lines with defined genetic alterations.Semantic proximity Read

Ultraviolet radiation accelerates NRas-mutant melanomagenesis: A cooperative effect blocked by sunscreen.Semantic proximity Read

UVB mutagenesis differs in <i>NRAS</i> - and <i>BRAF</i> -mutant mouse models of melanomaSemantic proximity Read

UV-induced somatic mutations elicit a functional T cell response in the YUMMER1.7 mouse melanoma model.Semantic proximity Read

A multi-step immune-competent genetic mouse model reveals phenotypic plasticity in uveal melanomaSemantic proximity Read

A novel mouse model demonstrates that oncogenic melanocyte stem cells engender melanoma resembling human disease.Semantic proximity Read

Mouse models of UV-induced melanoma: genetics, pathology, and clinical relevanceSemantic proximity Read

Enhanced BRAF engagement by NRAS mutants capable of promoting melanoma initiation.Semantic proximity Read

UVB mutagenesis differs in Nras- and Braf-mutant mouse models of melanoma.Semantic proximity Read

Functional differences drive the selection of NRAS mutants in melanomaSemantic proximity Read