Article
Ultraviolet radiation accelerates NRas-mutant melanomagenesis: A cooperative effect blocked by sunscreen.
Pigment cell & melanoma research - 1 Sept 2017
Hennessey Rebecca C, Holderbaum Andrea M, Bonilla Anamaria, Delaney Conor, Gillahan James E, Tober Kathleen L, Oberyszyn Tatiana M, Zippin Jonathan H, Burd Christin E
Abstract excerpt
To mitigate melanoma risk, sunscreen use is widely advocated; yet, the ability of sunscreens to prevent melanoma remains controversial. Here, we test the tenet that sunscreens limit melanoma risk by blocking ultraviolet radiation (UV)-induced DNA damage using murine models that recapitulate the genetics and spontaneous evolution of human melanoma. We find that a single, non-erythematous dose of UV dramatically...
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