Article
Enhanced BRAF engagement by NRAS mutants capable of promoting melanoma initiation.
Nature communications - 7 Jun 2022
Murphy Brandon M, Terrell Elizabeth M, Chirasani Venkat R, Weiss Tirzah J, Lew Rachel E, Holderbaum Andrea M, Dhakal Aastha, Posada Valentina, Fort Marie, Bodnar Michael S, Carey Leiah M, Chen Min, Burd Craig J, Coppola Vincenzo, Morrison Deborah K, Campbell Sharon L, Burd Christin E
Abstract excerpt
A distinct profile of NRAS mutants is observed in each tumor type. It is unclear whether these profiles are determined by mutagenic events or functional differences between NRAS oncoproteins. Here, we establish functional hallmarks of NRAS mutants enriched in human melanoma. We generate eight conditional, knock-in mouse models and show that rare melanoma mutants (NRAS G12D, G13D, G13R, Q61H, and Q61P) are poor...
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