Article
The OSUMMER lines: A series of ultraviolet-accelerated NRAS-mutant mouse melanoma cell lines syngeneic to C57BL/6.
Pigment cell & melanoma research - 1 Sept 2023
Murphy Brandon M, Jensen Daelin M, Arnold Tiffany E, Aguilar-Valenzuela Renan, Hughes Jase, Posada Valentina, Nguyen Kimberly T, Chu Vi T, Tsai Kenneth Y, Burd Craig J, Burd Christin E
Abstract excerpt
An increasing number of cancer subtypes are treated with front-line immunotherapy. However, approaches to overcome primary and acquired resistance remain limited. Preclinical mouse models are often used to investigate resistance mechanisms, novel drug combinations, and delivery methods; yet most of these models lack the genetic diversity and mutational patterns observed in human tumors. Here we describe a series...
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