Article

Functional differences drive the selection of NRAS mutants in melanoma

2021-01-17

Abstract excerpt

<h4>ABSTRACT</h4> Distinct NRAS mutants are enriched in various tumor types. Here, we generated a suite of fully congenic, conditional, Nras knock-in mouse models ( LSL-Nras Q61R, -K, -L, -H, -P, -Q; G12D and G13D, -R ) to test the hypothesis that melanocyte transformation requires functions specific to the NRAS mutants enriched in human melanoma (Q61R and Q61K). Consistent with the rarity of NRAS codon 12 and...

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Literature Corpus work: eeb19b21-5f56-55b2-b8ed-c7c8df69fc57
DOI: 10.1101/2021.01.15.426808

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