Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Prostate Stroma Increases the Viability and Maintains the Branching Phenotype of Human Prostate Organoids

27 Jan 2019

Abstract excerpt

The fibromuscular stroma of the prostate regulates normal epithelial differentiation and contributes to carcinogenesis in vivo. We developed and characterized a human 3D prostate organoid co-culture model that incorporates prostate stroma. Primary prostate stromal cells increased organoid formation and directed organoid morphology into a branched acini structure similar to what is observed in vivo. Organoid...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Prostate Cancer Diagnosis and Treatment
Share to Prostate Cancer Treatment and Research

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30735898
DOI: 10.1016/j.isci.2019.01.028

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 22 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Prostate Stroma Increases the Viability and Maintains the Branching Phenotype of Human Prostate OrganoidsPMID 30735898Read ↗

Generation of prostate cancer assembloids modeling the patient-specific tumor microenvironmentSemantic proximity Read ↗

Patient-derived prostate cancer organoids require α6-integrins for self-renewal and recapitulate genetic heterogeneity and histopathology of the original tumorsSemantic proximity Read ↗

Organoids: An Emerging Precision Medicine Model for Prostate Cancer ResearchSemantic proximity Read ↗

Xeno-free human iPSC-derived prostate organoid platform for multilineage differentiation and genetic manipulationSemantic proximity Read ↗

Differentiation of prostate epithelial cell cultures by matrigel/ stromal cell glandular reconstruction.Semantic proximity Read ↗

ECM-free patient-derived organoids preserve diverse prostate cancer lineages and uncover <i>in vitro</i> -enriched cell typesSemantic proximity Read ↗

Prostate organoids: emerging experimental tools for translational research.Semantic proximity Read ↗

Organoid Models for Cancer ResearchSemantic proximity Read ↗

High-throughput propagation of human prostate tissue from induced-pluripotent stem cellsSemantic proximity Read ↗

A comprehensive panel of three-dimensional models for studies of prostate cancer growth, invasion and drug responses.Semantic proximity Read ↗

Epidermal Growth Factor Is Essential for the Maintenance of Novel Prostate Epithelial Cells Isolated From Patient-Derived OrganoidsSemantic proximity Read ↗

Experimental prostate epithelial morphogenesis in response to stroma and three-dimensional matrigel culture.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.