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Parallel single-cell and bulk transcriptome analyses reveal key features of the gastric tumor microenvironment

22 Dec 2022

Abstract excerpt

BACKGROUND: The tumor microenvironment (TME) has been shown to strongly influence treatment outcome for cancer patients in various indications and to influence the overall survival. However, the cells forming the TME in gastric cancer have not been extensively characterized. RESULTS: We combine bulk and single-cell RNA sequencing from tumors and matched normal tissue of 24 treatment-naïve GC patients to better...

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PMID: 36550535
DOI: 10.1186/s13059-022-02828-2

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