Article

Delineating sex-dependent and anatomic decline of motor functions in the SOD1G93A mouse model of amyotrophic lateral sclerosis

2024-12-17

Abstract excerpt

The transgenic SOD1G93A mouse model is the most widely used animal model of amyotrophic lateral sclerosis (ALS), a fatal disease of motor neuron degeneration. While genetic background influences onset and progression variability of motor dysfunction, the C57BL/6 background most reliably exhibits robust ALS phenotypes; thus, it is the most widely used strain in mechanistic studies. In this model, paresis begins in...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8c70b8c8-fca6-5f2e-a27d-9c0a4d53a965
DOI: 10.1101/2024.12.17.628968

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Delineating sex-dependent and anatomic decline of motor functions in the SOD1G93A mouse model of amyotrophic lateral sclerosisDOI 10.1101/2024.12.17.628968Read

A comprehensive assessment of the SOD1G93A low-copy transgenic mouse, which models human amyotrophic lateral sclerosisSemantic proximity Read

New Insights on the Mechanisms of Disease Course Variability in ALS from Mutant SOD1 Mouse Models.Semantic proximity Read

Massive mitochondrial degeneration in motor neurons triggers the onset of amyotrophic lateral sclerosis in mice expressing a mutant SOD1.Semantic proximity Read

ALS phenotype is influenced by age, sex, and genetics: A population-based study.Semantic proximity Read

Effect of genetic background on onset and disease progression in the SOD1-G93A model of amyotrophic lateral sclerosis.Semantic proximity Read

Impact of Limb Phenotype on Tongue Denervation Atrophy, Dysphagia Penetrance, and Survival Time in a Mouse Model of ALS.Semantic proximity Read

Sensorimotor and cognitive functions in a SOD1(G37R) transgenic mouse model of amyotrophic lateral sclerosis.Semantic proximity Read

Skeletal muscle-restricted expression of human SOD1 causes motor neuron degeneration in transgenic miceSemantic proximity Read

Identification of B6SJL mSOD1(G93A) mouse subgroups with different disease progression rates.Semantic proximity Read

Sex biology in amyotrophic lateral sclerosisSemantic proximity Read

Dissociation of disease onset, progression and sex differences from androgen receptor levels in a mouse model of amyotrophic lateral sclerosis.Semantic proximity Read

Comparative study of behavioural tests in the SOD1G93A mouse model of amyotrophic lateral sclerosis.Semantic proximity Read