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Article

New Insights on the Mechanisms of Disease Course Variability in ALS from Mutant SOD1 Mouse Models.

Brain pathology (Zurich, Switzerland) - 1 Mar 2016

Nardo Giovanni, Trolese Maria Chiara, Tortarolo Massimo, Vallarola Antonio, Freschi Mattia, Pasetto Laura, Bonetto Valentina, Bendotti Caterina

Abstract excerpt

Amyotrophic Lateral Sclerosis (ALS) is a heterogeneous disease in terms of progression rate and survival. This is probably one of the reasons for the failure of many clinical trials and the lack of effective therapies. Similar variability is also seen in SOD1(G93A) mouse models based on their genetic background. For example, when the SOD1(G93A) transgene is expressed in C57BL6 background the phenotype is mild...

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Identifiers

PMID: 26780365
DOI: 10.1111/bpa.12351
PMCID: PMC8029191

Genes

SOD1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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