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Article

Impact of Limb Phenotype on Tongue Denervation Atrophy, Dysphagia Penetrance, and Survival Time in a Mouse Model of ALS.

Dysphagia - 1 Dec 2022

Mueller Marissa, Thompson Rebecca, Osman Kate L, Andel Ellyn, DeJonge Chandler A, Kington Sophia, Stephenson Zola, Hamad Ali, Bunyak Filiz, Nichols Nicole L, Lever Teresa E

Abstract excerpt

Current treatments for dysphagia in ALS do not target the underlying tongue weakness and denervation atrophy that is prevalent in spinal and bulbar ALS cases. To address this clinical gap, we studied the low copy number SOD1-G93A (LCN-SOD1) mouse model of ALS to quantify the impact of limb phenotype on tongue denervation atrophy, dysphagia penetrance, and survival time in preparation for future treatment-based...

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Source

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Identifiers

PMID: 35426522
DOI: 10.1007/s00455-022-10442-4
PMCID: PMC9568622

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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