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Article

Sensorimotor and cognitive functions in a SOD1(G37R) transgenic mouse model of amyotrophic lateral sclerosis.

Behavioural brain research - 20 Nov 2011

Filali Mohammed, Lalonde Robert, Rivest Serge

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a neurological disorder involving degeneration of motor neurons in brain and spinal cord, leading to progressive atrophy of skeletal muscles and, ultimately, paralysis and death. Copper-mediated oxidative damage is proposed to play a critical role in the pathogenesis of Cu/Zn superoxide dismutase (SOD1) - linked hereditary amyotrophic lateral sclerosis. To understand more...

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Identifiers

PMID: 21816178
DOI: 10.1016/j.bbr.2011.07.034

Genes

SOD1

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